Multipotent adult progenitor cells

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We have derived from normal human, mouse, and rat postnatal bone marrow primitive, multipotent adult progenitor cells MAPCs that can differentiate into most mesodermal cells and neuroectodermal cells in vitro and into all embryonic lineages in vivo. Here, we show that MAPCs can also differentiate into hepatocyte-like cells in vitro. These cells also acquired functional characteristics of hepatocytes: they secreted urea and albumin, had phenobarbital-inducible cytochrome p, could take up LDL, and stored glycogen.

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Richard T. Maziarz, Timothy Devos, Carlos R. Bachier, Steven C.

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Nanotechnology and multipotent adult progenitor cells in Reparative Medicine: therapeutic perspectives. The biology of stem cells is one of the most dynamic and promising fields of the biological sciences, since it is the basis for the development of organisms. Its biological complexity demands efforts from several lines of research aimed mainly at its therapeutic use. Nanotechnology has been emerging as a new field of study, which shows great potential in the treatment of various diseases.

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Andreu, Beatriz Pelacho, Juan J. Objectives: To assess the functional effects of multipotent adult progenitor cells MAPCs transplanted in a rat model of chronic myocardial infarction. Immunohistochemistry, electron microscopy and PCR were used to detect grafted cells.

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Lymphodepletion strategies are used in the setting of transplantation including bone marrow, hematopoietic cell, and solid organ to create space or to prevent allograft rejection and graft versus host disease. Following lymphodepletion, there is an excess of IL-7 available, and T cells that escape depletion respond to this cytokine undergoing accelerated proliferation. Moreover, this environment promotes the skew of T cells to a Th1 pro-inflammatory phenotype. Existing immunosuppressive regimens fail to control this homeostatic proliferative HP response, and thus the development of strategies to successfully control HP while sparing T cell reconstitution providing a functioning immune system represents a significant unmet need in patients requiring lymphodepletion.

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Metrics details. Preterm infants are at risk for hypoxic-ischemic encephalopathy. No therapy exists to treat this brain injury and subsequent long-term sequelae.

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