Taxane breast cancer

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Taxanes are a class of diterpenes. They were originally identified from plants of the genus Taxus yewsand feature a taxadiene core. Paclitaxel Taxol and docetaxel Taxotere are widely used as chemotherapy agents.

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Taxanes have remained a cornerstone of breast cancer treatment over the past three decades, improving the lives of patients with both early- and late-stage disease. The purpose of this review is to summarize the current role of taxanes, including an albumin-bound formulation that enhances delivery of paclitaxel to tumors, in the management of metastatic breast cancer MBC. Since the introduction of Cremophor EL-paclitaxel to the clinic in the mids, a substantial amount of investigation has gone into subjects such as formulation, dose, schedule, and taxane resistance, allowing physicians greater flexibility in treating patients with MBC.

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In fact,breast cancer is the most common cancer among women, except for non-melanoma skin cancer, and women living in North America have the highest rate of breast cancer in the world. Inaboutnew cases of invasive breast cancer will be diagnosed among women in the US, and an estimated 1, cases of breast cancer will be diagnosed in men. Breast cancer is the second leading cause of cancer death in women,exceeded only by lung cancer.

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What is paclitaxel? Who might be offered paclitaxel? How does paclitaxel work? How is paclitaxel given?

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Among the novel chemotherapeutic agents introduced in the last decade, the taxanes have emerged as the most powerful group of compounds, and results available so far confirm that they will be remembered in the future as the breast cancer chemotherapy of the s. Two taxanes are available paclitaxel and docetaxel and they share some characteristics, although they do have some significant differences both in terms of their preclinical profile and, most importantly, their clinical characteristics. There are three main clinical differences: different efficacy-toxicity ratio in relation to dose and schedule; different integrability in anthracycline- and taxane-containing regimens, secondary to differences in pharmacokinetic interactions with anthracyclines; and different level of synergism between each taxane and trastuzumab.

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A study found that getting Taxol chemical name: paclitaxel weekly had more benefits than getting Taxol every 3 weeks for women diagnosed with breast cancer that had spread to the lymph nodes or women diagnosed with breast cancer that hadn't spread to the lymph nodes but was considered high risk. Getting Taxol every week also had more benefits than getting Taxotere chemical name: docetaxel weekly or every 3 weeks for these women. In this study of 5, women, more women who received Taxol once a week were likely to be alive and free of breast cancer 5 years after being diagnosed compared to women who received Taxol every 3 weeks OR women who received Taxotere either weekly or every 3 weeks.

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Correspondence Address: Dr. Osama H. E-mail: ossama1 alexu.

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Among the novel chemotherapeutic drugs introduced in the s, the taxanes have emerged as the most powerful compounds in breast cancer. Both compounds, paclitaxel and docetaxel, have been evaluated in metastatic settings before adjuvant trials proceeded. Docetaxel was shown in several phase III trials to be superior, particularly in terms of survival, for salvaging polychemotherapies after failure of prior chemotherapy, including that with anthracyclines.

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Jump to navigation. We reviewed the evidence about the effect of taxane-containing chemotherapy regimens in women with metastatic breast cancer. This is an update of a Cochrane review first published in Treatment for women with metastatic breast cancer that is, cancer that has spread beyond the breast usually involves chemotherapy to try to shrink or slow the growth of the cancer.

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